Human papillomavirus (HPV) deregulation of Toll-like receptor 9

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Human papillomavirus (HPV) deregulation of Toll-like receptor 9

Persistent infection by high-risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.

متن کامل

P-33: Expression of Toll-Like Receptor 2-3 Genes in Human Sertoli Cells

Background: Toll-like receptors (TLRs) constitute a major part of innate immunity, which can distinguish pathogen associate molecular pattern. Sertoli cells create a special immunological niche that protects somniferous tubules from auto antigens and pathogens. These cells are the only somatic cells in somniferous that protect testis cells against pathogens. The purpose of this study was to eva...

متن کامل

Toll-Like Receptor 9 in Breast Cancer

Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune system, TLR9 mRNA and protein are also widely expressed in breast cancer cell lines and in clinical breast cancer specimens. Although synthetic TLR...

متن کامل

interaction of cpg-oligodeoxynucleotides with toll like receptor 9 induces apoptosis and modulates metaloproteinase-2 activity in human intestinal epithelium

recent reports have indicated different effects of immunostimulatory sequences containing cpg-oligodeoxynucleotides (odn) on various immune cells. however, the exact role of cpg-odn in the human gut is unclear. in the present study, we assessed potential effects of cpg-odn on non lymphoid cell (intestinal epithelial cell line ht-29) on a dose-response and time-course basis. intestinal epithelia...

متن کامل

The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter

Human papillomavirus type 16 (HPV16) and other oncogenic viruses have been reported to deregulate immunity by suppressing the function of the double-stranded DNA innate sensor TLR9. However, the mechanisms leading to these events remain to be elucidated. We show that infection of human epithelial cells with HPV16 promotes the formation of an inhibitory transcriptional complex containing NF-κBp5...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: OncoImmunology

سال: 2014

ISSN: 2162-402X

DOI: 10.4161/onci.27257